Apotex Vs Pliva Trazodone
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My pharmacy just switched manufacturers of my prescription trazodone 50mg. It used to be made by apotex now it is pliva and I am finding that the new pills are having little to no effect and I am starting to suffer discontinuation syndrome. I talked to my pharmacist and doctor and neither one could tell me what was causing this. I was just wondering if there is anyone out there who could shed some light on the subject.

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This is a very serious matter that should be brought to the attention of the FDA (Federal Food and Drug Administration). I have this same problem with Ativan.
The original manufacturer was Wyeth. When the patent expired and Ativan was sold to another phqrma co. Valeant, the medication became totally ineffective yet charged Brand prices!

Your psychiatrist needs to find for you another medication that can offer you the relief you desparately need now and if your current psychiatrist isn't helping you right away, find another now.

Good luck. We are all getting screwed by big PHARMA with the Government's complicity by its omission from this terrible situation with CNS meds.

ds

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Finally.....first night on APO slept well and it seem to be as effective as it was before. Not real crazy about breaking up the divi-dose (not scored well like the desyrel) but I'll take it. Were you able to find in San Diego ? You might try Point Loma Drugs on Rosecrans Michael the Pharmacist really helps me with my mess went I go home. Again thanks for all your help this forum really works

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It should be the same. It is just that they haven't made it in a while as you are aware!
I will try at Pharmacies here in San diego also.

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Thank you for the info. I just took it to pharmacy and they were able to order. This is a "new" product, is it as effective as APO? Again, thanks so much for your help.

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And all for the governments political corrections vis a vis, phar producers without any consideration at all for the human costs and deleterious effects on people's health and well being to kick from generic made here to made there to the next generic guy in the market place.

How about tightening that stupid 20% FDA uses to okay a generic for a brand to 2.5%? Too many really bad effects have occurred in some cases, death threatening events that noone seems to care about.

Why should sick people be put in this position vis a vis medication roulette, brand and generic, and also endure horrible shortages for no reason explained.

No standards; no QA/QC; no standardization of the efficacy of meds when the 'generic equivalent' comes to town.

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I hope this link works. It is the USA site for Apotex and shows that they have available to US pharmacies NEW prescrips for Trazadone:
apotex.com/us/en/products/detail.asp?m=51329

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Has anyone been successful getting Apotex T50 or other mgs? I tried again recently and Rite Aid's suppliers said they can't get it. I've been on Supplements (St John Worts and Tranquilnight) and doing pretty good....no longer captive to insurance companies, pharmacies, and the FDA. But, I'll try other pharmacies if anyone out there has been able to get it.

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Now that Apotex can ship to the US again, has anyone tried ordering from a Canadian pharmacy? Or getting a smaller independent pharmacy to stock it for you? Just curious. I have managed to keep enough Apotex to stay on it this whole time. But I am now running out.

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When I got my first prescription for Mylan 50 it was in desperation due to TEVA and PLIVA being totally ineffective. I made the decision to taper off the Mylan which I did during the last few months since the middle of May. I was very angry that I was made to feel hostage. I no longer have a full nights sleep but at least each time I wake up I can go back to sleep. It seems like I wake up every 2 or 3 hours. I do seem rested the next day and walk 6 miles every morning at rising feeling refreshed but the days of sleeping 8 straight hours are over for me with NO trazodone. When appotex returns I may try going back on it.

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Does anyone know if Teva traz and Pliva traz are essentially the same since they're owned by the same company? BTW, Mylan is not working for me at all. Has anyone tried increasing the does of Myland? Thanks,
Deb

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Thanks, I see that the apotex shortage is due to the fda ban just recently being removed so maybe they will be able to catch up. I also found that Mylan works fairly well (anything is 100 times better than plavia) but I see there is a shortage there too. Again, many thanks to you all.

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I have called everywhere and no one carries it anymore. I think it's been yanked from distribution for some reason. Traz by Mylan is the only alternative I've found that works for me. Good luck.

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ashp.org/DrugShortages/Current/Bulletin.aspx?id=681
Hope this works. (Appotex release has been delayed)

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Has anyone been successful in getting a script filled for Apotex Trazodone? If so what pharmacy? I tried with my Rite Aid and their supplier said they couldn't get it or know if they would be able to. I was hoping against hope that this waiting game was going to end, but I guess not. Thanks for all the advise and help.

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Good news everyone! I just went to the Apotex website and they are going to start shipping again to the US. They issued a press release about it on May 11. Just go to their website and you can see it.

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Have been taking Pliva generic trazodone for 3 months. I can't swallow the pills, so I chew them (yuk) BUT some of them are very bitter and some of the taste like chalk. I'm not sleeping alot of nights - hmmm, the chalk nights. Anyone know how to report this to FDA?

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Mine is Teva USA. Is that one any good? I haven't started it yet. I got off Remeron because of itching and am supposed to start Trazadone. Any info on Teva?

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Very useful info. I have been taking trazodone 75-150mg. qhs for many years. Recently got 150mg. Pliva at CVS. It is a HUGE trapezoidal-shape pill (sharp angles) which I've had trouble swallowing. I'm curious as to why some generics are much larger than others (and the brand in most cases). 'Fillers' seems to be the logical answer.
I got a flat oval tab (trazodone) from WalMart not long ago and will try that. CVS said they cannot get other generics. I am a bit catious because there has been a merger/ acquisition between Pliva, Barr, and TEVA ( not sure of when) and have no idea how that will play in.
Thanks all for your reports of side effects of this generic. I have been experiencing some mood fluctuations recently (more than my usual) and didn't even think of the traz change until I searched about the size/shape issue.
I say NO to most generics of maintenance meds. My endocrinologist INSISTS on Synthroid--no levothroid or other substitutions. I have noticed a huge diff btwn Klonopin and generic clonazepam which I take qhs for bruxism (potentially cause by SSRIs).




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Costco just refilled my Apo (tex) T50 with Pliva last week and I couldn't fall asleep for 4 hours every night. Had severe withdrawal syndrome so had Primary Phys call in a scrip to Walmart for Mylan 50mg. after calling MANY pharmacies in town. No APO anywhere here in san diego, only Pliva and Teva. Slept thru the night with the Mylan the last two nights. No grogginess and feeling alert thru the day. Thank God!

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My pharmacy just switched to Pliva and I started the Trazodone 3 nights ago. Can't go to sleep without taking 50% more than I'm used to AND getting severe headaches in the middle of the night. Anyone else experienced these headaches with the Pliva?

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